Ordinary heart cells transformed into ‘biological pacemakers’
Tuesday, December 18th, 2012
Taking a major step forward in the decade-long search for a biological therapy to correct erratic and failing heartbeats, Cedars-Sinai Heart Institute researchers have reprogrammed ordinary heart cells to become exact replicas of highly specialized pacemaker cells by injecting a single gene (Tbx18).
“Although we and others have created primitive biological pacemakers before, this study is the first to show that a single gene can direct the conversion of heart muscle cells to genuine pacemaker cells. The new cells generated electrical impulses spontaneously and were indistinguishable from native pacemaker cells,” said Hee Cheol Cho, PhD., a Heart Institute research scientist.
Pacemaker cells generate electrical activity that spreads to other heart cells in an orderly pattern to create rhythmic muscle contractions. If these cells go awry, the heart pumps erratically at best; patients healthy enough to undergo surgery often look to an electronic pacemaker as the only option for survival.
Gaining weight back after intentional weight loss is associated with negative long-term effects on some cardiometabolic (CM) risk factors in post-menopausal women, researchers say.
Erectile dysfunction, which typically focus on a man’s inability to have sex, has a more devastating issue that could be behind having difficulty maintaining an erection – heart disease, researchers say.
Adults who engage in at least 150 minutes of moderate to vigorous activity each week live longer than inactive adults, a new study has found.
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